This is the video for Merlin Mann’s Inbox Zero talk, presented in July of 2007 at Google. I’ve been using this method for a while now and I have to say, it works great for me!
I used to have tons of folders to organize my mail, but having too many folders simply doesn’t work. My mail was accumulating on Inbox because I was losing too much time deciding where I should put each mail. Now I have just a couple folders and Google desktop search to help me find my mail. My Inbox is always clean!